• GSIs were shown to effectively decrease A levels at doses

  2021-10-28

  

  GSIs were shown to effectively decrease Aβ levels at doses close to or higher than their IC50 values in cell culture models. Surprisingly, they also slightly increase Aβ levels at low doses, (significantly below the IC50) also known as “Aβ rise”, due to various mechanisms including inhibition of cel

• Gal is a amino acid residue peptide comprising amino

  2021-10-28

  

  Gal is a 29-amino L-703,664 succinate sale residue peptide, comprising 30 amino acids in humans, isolated from the porcine intestine 30 years ago (Tatemoto et al., 1983). It has been shown to be involved in the regulation of numerous processes, including neuroendocrine control of systems such as the

• G quadruplex structures can be resolved by helicases

  2021-10-28

  

  G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer tyrosine kinase receptor [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and

• Fpr appears to be an

  2021-10-28

  

  Fpr2 appears to be an indispensable component of the signaling chain governing dendritic cell trafficking in allergic airway inflammation (Chen et al., 2010). The FPR3 agonist FL2 is chemoattractant for dendritic cells, but its biological role in vivo is yet to be defined. Within the inflammatory s

• In the phylum Cnidaria which separated from the main

  2021-10-28

  

  In the phylum Cnidaria, which separated from the main line of Metazoa early during evolution, FGFR signaling is essential during development and morphogenesis. Two FGFRs and two FGFs antagonistically control formation of the apical organ in the anthozoan Nematostella and target the MAPK pathway (Ren

• Canonical and non canonical Wnt

  2021-10-28

  

  Canonical and non-canonical Wnt signaling pathways play essential roles in various cellular activities, including cell fate determination, proliferation, migration and gene expression [57]. The canonical Wnt pathway (β-catenin dependent pathway), is activated by the binding of Wnt ligands, leading t

• Autophagy plays a multifaceted role

  2021-10-28

  

  Autophagy plays a multifaceted role in regulating both the quality and quantity of protein (e.g., protein half-life and activity) and organelles (e.g., mitochondrial number and function), thus determining cell fate [15]. The induction of autophagy has been generally considered a programmed cell surv

• br Experimental br Acknowledgments We

  2021-10-28

  

  Experimental Acknowledgments We thank Mintek and Rhodes University for generous financial support and permission to publish these findings. T.O.O. gratefully acknowledges Obafemi Awolowo University, Ile-Ife, Nigeria for study leave. Introduction There are ∼35.3 million people living with H

• Myelination by oligodendrocytes is required

  2021-10-28

  

  Myelination by oligodendrocytes is required for saltatory nerve impulse conduction and proper CNS function (Bercury and Macklin, 2015). Defects in myelination and remyelination impair saltatory nerve conduction and functional connectivity leading to cognitive, behavioral, and motor deficits in neuro

• br To explore further the functional impact

  2021-10-28

  

  To explore further the functional impact of the similarity of the UTY and KDM6A proteins, the FANTOM5 human dataset was analysed to determine whether or not the genes were expressed at the same time in the same tissues (which would suggest that they are controlled by the same regulators) or with o

• Bile acids synthesized in the liver are secreted

  2021-10-27

  

  Bile acids synthesized in the liver are secreted into the intestinal tract to facilitate the digestion and medetomidine of nutrients. Most bile acids are reabsorbed by the ileum and are transported back to the liver via the portal blood circulation. Recently, bile acids have also been considered as

• Three main mechanisms have been proposed

  2021-10-27

  

  Three main mechanisms have been proposed for the secretion of active forms of hedgehog ligands: first, construction of a multimeric molecule with lipid moieties placed on the inside, making a soluble Hh protein which can diffuse from the membrane; second, function of dispatched proteins through pack

• Although it is currently unknown why the longer

  2021-10-27

  

  Although it is currently unknown why the longer splice variant found in the human has not been found in any other species, similar results have been reported for other receptors, including the 8-pCPT-2-O-Me-cAMP-AM receptor splice variant ERbeta2 identified in human and primate, but not other specie

• To determine the functional consequences

  2021-10-27

  

  To determine the functional consequences of HIV gp120 binding to vaginal epithelial cells, an annotation clustering of the differentially expressed genes was performed. The top enriched biological processes included an inflammatory immune response, defense response and the pathways included the SODD

• The existence of EAAT subtypes raises

  2021-10-27

  

  The existence of 5 EAAT subtypes raises obvious questions as to the cellular and anatomical distribution of the various transporters (for review, see Gegelashvili & Schousboe, 1998, Danbolt, 2001). While difference in techniques (i.e., protein vs. mRNA), reagents, and preparations (i.e., in vivo vs.

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