• Imatinib is a well known anticancer drug used

  2023-04-07

  

  Imatinib is a well-known anticancer drug used in Chronic Myeloid Leukemia (CML) against the altered expression/activity of tyrosine kinase resulting from the fusion of BCR-ABL in leukemic blasts. It has been demonstrated that Imatinib can induce autophagy in BCR-ABL expressing Carbetocin (K562 cell

• We next sought to determine the kinase responsible for

  2023-04-06

  

  We next sought to determine the kinase responsible for IR-induced phosphorylation of 53BP1. Because the sites under investigation all lie in a consensus sequence for ATM, ATR and DNA-PK, that are all activated by IR, the involvement of each of these kinases was investigated. Preincubation of ARCA m

• There is a delicate balance between

  2023-04-06

  

  There is a delicate balance between ROS generation and scavenging by the protective antioxidant defenses in the cell. Antioxidant systems present in the f4 cat sale include enzymes like superoxide dismutase (SOD), catalases, glutathione peroxidases (GPxs) and peroxiredoxins (PRxs) (Fig. 3) [38]. SO

• Obesity is associated with chronic low

  2023-04-06

  

  Obesity is associated with chronic low-grade ecopipam resulting from increased M1 macrophage infiltration into adipose tissue, which can subsequently lead to the development of insulin resistance. Previously, we reported that LFE and FSB both reduced body weight gain in high fat diet-induced obese

• The crucial role of AP in establishing and maintaining cell

  2023-04-06

  

  The crucial role of AP-1 in establishing and maintaining cell type-specific gene expression programs and cell identity is further apparent during reprogramming of mouse embryo fibroblasts (MEFs) into iPSCs with either Oct4/Sox2/Klf4/cMyc (OSKM ) factors , or chemicals . Using ATAC-seq to profile ch

• Bamboo shoots with their high nutritive http www

  2023-04-06

  

  Bamboo shoots, with their high nutritive and therapeutic value, are now used for food fortification (Nirmala & Bisht, 2017). Several value-added products such as nuggets, crackers, chutney, snacks, cookies, cakes, chappaties, and buns have been prepared from bamboo shoots (Table 3). Dietary fiber fr

• The AT hook motif is highly conserved

  2023-04-06

  

  The AT-hook motif is highly conserved in evolution from bacteria to humans and is found in one or more copies in a large number of other, non-HMGA, proteins, many of which are transcription factors or are involved in chromatin remodeling [8]. For example, AT-hook peptide motifs are essential compone

• br Experimental section br Abbreviations

  2023-04-06

  

  Experimental section Abbreviations PSA, puromycin–sensitive aminopeptidase; APN, aminopeptidase N; AML, acute myeloid Leukemia; ALL, acute lymphoblastic leukemia; AADR, amino corticosterone deprivation response; PAN, puromycin aminonucleoside; DCC, dicyclohexyl carbodiimide; NHS, N–hydroxy su

• Since the first studies of betaine aldehyde oxidation in

  2023-04-06

  

  Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other 9-Phenanthrol receptor as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack

• galanin receptor Our findings establish a critical link

  2023-04-06

  

  Our findings establish a critical link between HemAC-Lm dimeric structure and cAMP synthesis that helps in explaining how globin-A domain influences AC domain. The following possible homodimeric structure of wild type full length HemAC-Lm has been proposed to explain the role of this globin-A domain

• Although plant Aurora kinases can be clearly grouped

  2023-04-06

  

  Although plant Aurora kinases can be clearly grouped into functional clades, the roles of the respective clades does not seem to be evolutionarily conserved. AtAurora 1 labels kinetochore microtubules [19], similarly to mammalian Aurora A, while its targeting to the cell plate resembles features of

• br Results br Discussion Using

  2023-03-31

  

  Results Discussion Using primarily an electrophysiological analysis of dysbindin-deficient hippocampal neurons in cultures and slices, we have uncovered a previously unreported role for dysbindin in enhancing CA3–CA1 AMPAR-mediated transmission. An earlier study, however, has reported a reduct

• Cy7.5 maleimide(non-sulfonated) synthesis Numerous studies h

  2023-03-28

  

  Numerous studies have shown that ω-3 PUFA incorporation into the lipid raft can affect the distribution and function of protein in the lipid raft by altering raft composition [25], [26], [27]. For example, DHA treatment excluded phospholipase D (PLD) from lipid raft toward non-lipid raft, resulting

• The specific binding domain between PGK in group

  2023-03-28

  

  The specific binding domain between PGK in group B strepotocci (GBS) and actin had been reported . PGK as the actin-binding protein identified in TMW 1.1434, which displayed highly significant adhesion was investigated for the binding sites and compared to bacteria with less strong adhesion to acti

• br Materials and methods Bacterial strains

  2023-03-27

  

  Materials and methods Bacterial strains and growth conditions. Escherichia coli TOP10 and E. coli BL21Star (DE3) (ThermoFisher, Waltham, MA) were grown at 37 °C in Luria broth (LB) or LB-agar containing kanamycin (50 μg/ml). Bioinformatic analyses. The amino RN486 sequence of Rv2477c was obtain

16011 records 335/1068 page Previous Next First page 上5页 331332333334335 下5页 Last page